CHRNA6

Description		cholinergic receptor nicotinic alpha 6 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Acetylcholine-gated Channel Complex Membrane Cation Channel Complex Presynaptic Membrane Neuron Projection Synapse Postsynaptic Membrane Synaptic Membrane Dopaminergic Synapse Neurotransmitter Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Protein Binding Acetylcholine Receptor Activity Acetylcholine-gated Monoatomic Cation-selective Channel Activity
	Biological Process	Monoatomic Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Regulation Of Dopamine Secretion Monoatomic Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Membrane Depolarization Regulation Of Postsynaptic Membrane Potential Excitatory Postsynaptic Potential Acetylcholine Receptor Signaling Pathway Presynaptic Modulation Of Chemical Synaptic Transmission
Pathways		Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Succinylcholine Butabarbital Cisatracurium Ethanol Varenicline Cytisine
Diseases
GWAS		Nicotine dependence ( 26440539) Pelvic organ prolapse (moderate/severe) ( 26545240) Smoking behavior ( 20418888)
Interacting Genes		1 interacting genes: PPP3R1
Entrez ID		8973
HPRD ID		06056
Ensembl ID		ENSG00000147434
Uniprot IDs		Q15825
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcium Ion Import Calcium-dependent Protein Serine/threonine Phosphatase Activity Lung Epithelial Cell Differentiation Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Protein Serine/threonine Phosphatase Complex Regulation Of Synaptic Vesicle Cycle Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Calcium Ion Import Across Plasma Membrane Schwann Cell Development Parallel Fiber To Purkinje Cell Synapse Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin Complex Lung Cell Differentiation Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Calcineurin-NFAT Signaling Cascade Myelination In Peripheral Nervous System Calcineurin-mediated Signaling Postsynaptic Modulation Of Chemical Synaptic Transmission Branching Involved In Blood Vessel Morphogenesis Regulation Of Calcineurin-mediated Signaling Negative Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcineurin-NFAT Signaling Cascade Hippocampal Mossy Fiber To CA3 Synapse Regulation Of Calcium Ion Import Phosphatase Binding Negative Regulation Of Calcium Ion Transport Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcium Ion Transmembrane Transport Glial Cell Development Negative Regulation Of Cation Transmembrane Transport Regulation Of Receptor Internalization Negative Regulation Of Monoatomic Ion Transmembrane Transport Epithelial To Mesenchymal Transition Schaffer Collateral - CA1 Synapse Regulation Of Calcium-mediated Signaling Negative Regulation Of Monoatomic Ion Transport Myelination Axon Ensheathment Positive Regulation Of Calcium Ion Transport Mesenchymal Cell Differentiation Sarcolemma Negative Regulation Of Transmembrane Transport Positive Regulation Of Cation Transmembrane Transport Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Monoatomic Ion Transmembrane Transport Import Into Nucleus Protein Import Into Nucleus Branching Morphogenesis Of An Epithelial Tube
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