PHOX2B

Description		paired like homeobox 2B
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Neuron Migration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Noradrenergic Neuron Differentiation Noradrenergic Neuron Development Brainstem Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Population Proliferation Glial Cell Differentiation Regulation Of Gene Expression Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Activity Cell Differentiation In Hindbrain Medullary Reticular Formation Development Hindbrain Tangential Cell Migration Neuron Differentiation Skeletal Muscle Cell Differentiation Type B Pancreatic Cell Proliferation Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Development Autonomic Nervous System Development Enteric Nervous System Development Sympathetic Nervous System Development Parasympathetic Nervous System Development Neuron Development Inner Ear Development Efferent Axon Development In A Lateral Line Nerve Membrane Depolarization Respiratory System Development Retrotrapezoid Nucleus Neuron Differentiation Sympathetic Ganglion Development Cellular Response To Carbon Dioxide Dopaminergic Neuron Differentiation Cellular Response To BMP Stimulus Motor Neuron Migration Positive Regulation Of Cold-induced Thermogenesis Neural Crest Cell Migration Involved In Autonomic Nervous System Development Negative Regulation Of Type B Pancreatic Cell Proliferation
Pathways
Drugs
Diseases		Congenital central hypoventilation syndrome (CCHS)
GWAS		Bone mineral density (femoral neck) ( 26911590) Hirschsprung disease ( 27702942)
Novel Interacting Genes		1 novel interacting genes: PTGFR
Interacting Genes
Entrez ID		8929
HPRD ID		09157
Ensembl ID		ENSG00000109132
Uniprot IDs		Q99453
PDB IDs		7MJA 8EK5 8P7G 8PTL 8PUI
Enriched GO Terms of Interacting Partners?		Prostaglandin F Receptor Activity Cellular Response To Prostaglandin D Stimulus Parturition Cellular Response To Prostaglandin Stimulus Response To Estradiol
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