PROZ

Description		protein Z, vitamin K dependent plasma glycoprotein
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Proteolysis Blood Coagulation Hemostasis
Pathways		Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Factor VII ( 17903294) Food allergy (parent-of-origin effect) ( 29489655) Reticulocyte fraction of red cells ( 32888494)
Novel Interacting Genes		2 novel interacting genes: IRS2 TUBGCP3
Interacting Genes		1 interacting genes: F2
Entrez ID		8858
HPRD ID		07182
Ensembl ID		ENSG00000126231
Uniprot IDs		P22891
PDB IDs		3F1S 3H5C
Enriched GO Terms of Interacting Partners?		Regulation Of Hormone Secretion Regulation Of Insulin Secretion Regulation Of Protein Secretion Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Insulin Secretion Thrombospondin Receptor Activity Positive Regulation Of Protein Secretion Positive Regulation Of Protein Transport Positive Regulation Of Hormone Secretion Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Type B Pancreatic Cell Proliferation Neutrophil-mediated Killing Of Gram-negative Bacterium Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Secretion By Cell Polar Microtubule Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phosphatidylinositol 3-kinase Activator Activity Thrombin-activated Receptor Signaling Pathway Neutrophil-mediated Killing Of Bacterium Cytolysis By Host Of Symbiont Cells Positive Regulation Of Protein Localization Regulation Of Protein Transport Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Fatty Acid Transport Regulation Of Long-chain Fatty Acid Import Into Cell Response To Endothelin Cellular Response To Endothelin Gamma-tubulin Complex Negative Regulation Of Fibrinolysis Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Astrocyte Differentiation Negative Regulation Of B Cell Apoptotic Process Positive Regulation Of Fatty Acid Oxidation Microtubule Minus-end Binding Intracellular Chemical Homeostasis Regulation Of Establishment Of Protein Localization Regulation Of Hormone Levels Regulation Of Fibrinolysis Regulation Of Fatty Acid Beta-oxidation Phosphatidylinositol 3-kinase Binding Positive Regulation Of Glycogen Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Negative Regulation Of Platelet Activation Type B Pancreatic Cell Proliferation Regulation Of Secretion By Cell
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