HSD17B6

Description		hydroxysteroid 17-beta dehydrogenase 6
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Endoplasmic Reticulum Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Catalytic Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity All-trans-retinol Dehydrogenase (NAD+) Activity Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Androsterone Dehydrogenase [NAD(P)+] Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Testosterone Dehydrogenase (NAD+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Testosterone Dehydrogenase (NADP+) Activity
	Biological Process	Lipid Metabolic Process Androgen Biosynthetic Process Androgen Catabolic Process Steroid Metabolic Process Retinol Metabolic Process Brexanolone Catabolic Process
Pathways		The canonical retinoid cycle in rods (twilight vision)
Drugs
Diseases
GWAS		Asthma ( 31619474) Cerebral amyloid deposition (PET imaging) ( 30361487) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Platelet aggregation ( 20526338) Platelet count ( 27863252) Red blood cell count ( 29403010)
Novel Interacting Genes		1 novel interacting genes: PDE2A
Interacting Genes
Entrez ID		8630
HPRD ID		09431
Ensembl ID		ENSG00000025423
Uniprot IDs		A0A219K5H4 A0A219K684 O14756
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To CGMP 3',5'-cyclic-AMP Phosphodiesterase Activity CGMP Metabolic Process Cyclic Nucleotide Catabolic Process 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cellular Response To Macrophage Colony-stimulating Factor Stimulus Response To Macrophage Colony-stimulating Factor Negative Regulation Of CGMP-mediated Signaling 3',5'-cyclic-GMP Phosphodiesterase Activity Phosphate Ion Binding Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus CAMP Binding CGMP Catabolic Process TPR Domain Binding Regulation Of CGMP-mediated Signaling Monocyte Differentiation 3',5'-cyclic-nucleotide Phosphodiesterase Activity Response To 2,3,7,8-tetrachlorodibenzodioxine CGMP Binding Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine Positive Regulation Of Vascular Permeability Negative Regulation Of Vascular Permeability Response To CGMP Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Heart Valve Development Negative Regulation Of CAMP/PKA Signal Transduction CGMP-mediated Signaling Aorta Development Ventricular Septum Development Establishment Of Endothelial Barrier Cyclic Purine Nucleotide Metabolic Process Artery Development Cardiac Septum Development Regulation Of Vascular Permeability Regulation Of CAMP/PKA Signal Transduction Endothelial Cell Development Phosphoric Diester Hydrolase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Cellular Response To CAMP Cellular Response To Transforming Growth Factor Beta Stimulus Synaptic Membrane Cellular Response To Xenobiotic Stimulus Response To Transforming Growth Factor Beta Cellular Response To Mechanical Stimulus Purine Ribonucleotide Catabolic Process Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Purine Nucleotide Catabolic Process Response To CAMP Nucleotide Catabolic Process
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