HELZ2

Name	helicase with zinc finger 2
Structure	No pdb structure
Interactors	2 interactors: PPARA PPARG
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane P Granule
	Molecular Function	Nucleotide Binding 3'-5'-RNA Exonuclease Activity DNA Binding Transcription Coactivator Activity RNA Binding RNA Helicase Activity Helicase Activity Nuclease Activity Exonuclease Activity RNA Nuclease Activity Protein Binding ATP Binding Zinc Ion Binding Exoribonuclease II Activity Hydrolase Activity ATP Hydrolysis Activity Metal Ion Binding
	Biological Process	Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Positive Regulation Of Transcription By RNA Polymerase II
Pathways	BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
GWAS	Basophil count ( 32888494 ) Daytime nap ( 33568662 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Lymphocyte percentage of white cells ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Refractive error ( 32231278 )
Entrez ID	85441
HPRD ID	11459
Ensembl ID	ENSG00000130589
Uniprot IDs	A0AAA9XBX5 Q9BYK8
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Lipid Storage Negative Regulation Of MiRNA Transcription Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Fatty Acid Metabolic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Lipid Storage Nuclear Receptor Activity Regulation Of Cardiac Muscle Hypertrophy Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Regulation Of Fatty Acid Metabolic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Circadian Rhythm Regulation Of Ketone Metabolic Process RNA Polymerase II Transcription Regulator Complex Regulation Of Lipid Transport Positive Regulation Of Lipid Metabolic Process Hormone-mediated Signaling Pathway Response To Nutrient Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Small Molecule Metabolic Process Response To Insulin Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Blood Pressure Negative Regulation Of Inflammatory Response DNA-binding Transcription Factor Binding Positive Regulation Of Transformation Of Host Cell By Virus Intracellular Receptor Signaling Pathway Regulation Of Muscle System Process Rhythmic Process Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Adiponectin Secretion DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Negative Regulation Of Defense Response Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Fatty Acid Metabolic Process Response To Hypoxia Response To Peptide Hormone Response To Decreased Oxygen Levels Regulation Of Transformation Of Host Cell By Virus Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Response To Oxygen Levels Regulation Of Cellular Response To Growth Factor Stimulus Cellular Response To Fructose Stimulus