MYLK2

Description		myosin light chain kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Sarcomere Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Myosin Light Chain Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Myosin Light Chain Binding
	Biological Process	Striated Muscle Contraction Signal Transduction Neuromuscular Synaptic Transmission Positive Regulation Of Gene Expression Skeletal Muscle Satellite Cell Differentiation Peptidyl-threonine Phosphorylation Regulation Of Muscle Filament Sliding Skeletal Muscle Cell Differentiation Protein Autophosphorylation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways
Drugs		Prenylamine Fostamatinib
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean corpuscular volume ( 27863252) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Parkinson's disease ( 32201043) Platelet count ( 27863252 32888494) Plateletcrit ( 27863252 32888494)
Interacting Genes		3 interacting genes: CFTR SNCA TRIM54
Entrez ID		85366
HPRD ID		05953
Ensembl ID		ENSG00000101306
Uniprot IDs		Q9H1R3
PDB IDs		2LV6 3KF9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Exocytosis Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Exocytosis Positive Regulation Of Anion Channel Activity Organic Hydroxy Compound Transport Positive Regulation Of Monoatomic Ion Transport Negative Regulation Of Supramolecular Fiber Organization Regulation Of Norepinephrine Uptake Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Positive Regulation Of Monoatomic Anion Transport Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Enamel Mineralization Negative Regulation Of Dopamine Metabolic Process Microtubule Binding Regulation Of Serotonin Uptake Regulation Of Microtubule-based Process Regulation Of Monoatomic Ion Transmembrane Transport Transepithelial Water Transport Positive Regulation Of Secretion By Cell Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process Positive Regulation Of Secretion Positive Regulation Of Tooth Mineralization Dopamine Uptake Involved In Synaptic Transmission Chloride Channel Inhibitor Activity Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Response To Iron(II) Ion Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Regulation Of Chaperone-mediated Autophagy Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Oxidative Phosphorylation Enzyme Binding
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