PARG

Description		poly(ADP-ribose) glycohydrolase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Nuclear Body
	Molecular Function	Poly(ADP-ribose) Glycohydrolase Activity Protein Binding Hydrolase Activity
	Biological Process	Carbohydrate Metabolic Process Regulation Of DNA Repair Base-excision Repair, Gap-filling DNA Damage Response Nucleotide-sugar Metabolic Process ATP Generation From Poly-ADP-D-ribose
Pathways		POLB-Dependent Long Patch Base Excision Repair
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163) Femur bone mineral density x serum urate levels interaction ( 34046847) Prostate cancer ( 25939597)
Interacting Genes		3 interacting genes: BRCA1 CASP3 OGT
Entrez ID		8505
HPRD ID		04611
Ensembl ID		ENSG00000227345
Uniprot IDs		Q86W56
PDB IDs		4A0D 4B1G 4B1H 4B1I 4B1J 5A7R 5LHB 6HH6 6HMK 6HML 6HMM 6HMN 6O9X 6O9Y 6OA0 6OA1 6OA3 6OAK 6OAL 7KFP 7KG0 7KG1 7KG6 7KG7 7KG8
Enriched GO Terms of Interacting Partners?		Pyroptotic Inflammatory Response Histone H2AK127 Ubiquitin Ligase Activity Response To Tumor Necrosis Factor Histone H2AK129 Ubiquitin Ligase Activity Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway BRCA1-BARD1 Complex Regulation Of Lipid Biosynthetic Process Negative Regulation Of Gene Expression Response To Monosaccharide Response To Carbohydrate Response To Glucose Phospholipase A2 Activator Activity Protein Processing Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Lipid Metabolic Process Protein Modification Process Negative Regulation Of Centriole Replication BRCA1-B Complex Nuclear Ubiquitin Ligase Complex Cellular Response To Indole-3-methanol Regulation Of Small Molecule Metabolic Process BRCA1-C Complex Negative Regulation Of Cell Cycle Response To Indole-3-methanol Intracellular Signal Transduction Apoptotic Signaling Pathway Regulation Of Programmed Cell Death Response To Anesthetic Protein Maturation Anterior Neural Tube Closure Rhythmic Process Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Death-inducing Signaling Complex Luteolysis Glial Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Positive Regulation Of Pyroptotic Inflammatory Response Regulation Of Transcription By Glucose Response To Cobalt Ion Response To Radiation
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