RERG

Description		RAS like estrogen regulated growth inhibitor
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Nuclear Estrogen Receptor Binding
	Biological Process	Small GTPase-mediated Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Hormone Negative Regulation Of Cell Growth
Pathways
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronic kidney disease ( 31152163) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31015462 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gastroesophageal reflux disease ( 34187846) Glomerular filtration rate (creatinine) ( 28452372) Hematocrit ( 32888494) Hemoglobin ( 32888494) Iris color (L* coordinate) ( 30895295) Red blood cell count ( 32888494) Urate levels ( 31578528) Urate levels in overweight individuals ( 25811787)
Novel Interacting Genes		1 novel interacting genes: EXOSC8
Interacting Genes
Entrez ID		85004
HPRD ID		15238
Ensembl ID		ENSG00000134533
Uniprot IDs		Q96A58
PDB IDs		2ATV
Enriched GO Terms of Interacting Partners?		U5 SnRNA 3'-end Processing Exoribonuclease Complex U1 SnRNA 3'-end Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance TRNA Decay RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) U4 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RRNA Catabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) SnRNA 3'-end Processing MRNA 3'-UTR AU-rich Region Binding SnRNA Processing Nuclear RNA Surveillance RNA Surveillance SnRNA Metabolic Process RNA 3'-end Processing Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Fibrillar Center TRNA Metabolic Process RNA Catabolic Process RRNA Processing RRNA Metabolic Process Nucleobase-containing Compound Catabolic Process
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