ADO

Description		2-aminoethanethiol dioxygenase
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GO Annotations	Cellular Component	Mitochondrion Cytosol
	Molecular Function	Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen Metal Ion Binding Cysteamine Dioxygenase Activity Dioxygenase Activity
	Biological Process	Cellular Response To Hypoxia
Pathways		Degradation of cysteine and homocysteine
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Atopic dermatitis ( 23042114) Behcet's disease ( 33393726) Bipolar disorder ( 34002096) Breast size ( 22747683) Crohn's disease ( 28067908 22412388) Cutaneous psoriasis ( 26626624) Daytime nap ( 33568662) Diastolic blood pressure ( 27618447 27841878 27618448) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Ewing sarcoma ( 22327514) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Monocyte count ( 27863252 32888494) Platelet count ( 32888494) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 27841878 27618447) Ulcerative colitis ( 28067908) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 12 weeks) ( 28437668) Vogt-Koyanagi-Harada syndrome ( 25108386)
Interacting Genes		2 interacting genes: CAP2 DISC1
Entrez ID		84890
HPRD ID		12566
Ensembl ID		ENSG00000181915
Uniprot IDs		B3KXN9 Q96SZ5
PDB IDs		7REI 8U9J 8UAN
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Presynaptic Cytoskeleton Organization CAMP-mediated Signaling Presynaptic Actin Cytoskeleton Organization Radial Glia-guided Pyramidal Neuron Migration Pyramidal Neuron Migration To Cerebral Cortex Cerebral Cortex Radial Glia-guided Migration Central Region Of Growth Cone Positive Regulation Of Lyase Activity Adenylate Cyclase Binding Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cyclase Activity Cytoskeleton Organization Positive Regulation Of Neuroblast Proliferation Detection Of Temperature Stimulus Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Mitochondrial Calcium Ion Homeostasis Cell Proliferation In Forebrain Detection Of Temperature Stimulus Involved In Sensory Perception Glial Cell Migration Cerebral Cortex Radially Oriented Cell Migration Protein Localization To Centrosome Regulation Of Synapse Maturation Cerebral Cortex Cell Migration Dynein Complex Regulation Of Neuroblast Proliferation Telencephalon Cell Migration Response To Electrical Stimulus Kinesin Binding Forebrain Cell Migration Kinesin Complex Positive Regulation Of Axon Extension Ciliary Base Protein Localization To Cytoskeleton Intermediate Filament Cytoskeleton Non-motile Cilium Assembly Regulation Of Dendritic Spine Development Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Cell-matrix Adhesion Neuron Cellular Homeostasis Regulation Of Synaptic Transmission, Glutamatergic Positive Regulation Of Axonogenesis Cell Body Regulation Of Axon Extension TOR Signaling Identical Protein Binding Intracellular Signal Transduction Microtubule Organizing Center Regulation Of Neural Precursor Cell Proliferation
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