AGBL4

Description		AGBL carboxypeptidase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Centriole Cytosol Cytoskeleton Microtubule Cytoskeleton Axon Ciliary Basal Body Cell Projection Axon Cytoplasm
	Molecular Function	Carboxypeptidase Activity Metallocarboxypeptidase Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Tubulin Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Proteolysis Negative Regulation Of Cell Population Proliferation Central Nervous System Neuron Development Protein Deglutamylation C-terminal Protein Deglutamylation Protein Side Chain Deglutamylation Defense Response To Virus Axonal Transport Anterograde Axonal Transport Of Mitochondrion Retrograde Axonal Transport Of Mitochondrion Regulation Of Blastocyst Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol dependence or heroin dependence or methamphetamine dependence ( 31462767) Atrial fibrillation ( 30061737) Body mass index ( 25673413 28892062) Broad depression or schizophrenia ( 30626913) Liver injury in anti-tuberculosis drug treatment ( 27671213) Metabolite levels ( 23823483) Postcentral gyrus volume ( 31530798) Reaction time ( 29844566) Smoking initiation ( 33082346) Systolic blood pressure ( 30224653) Waist circumference ( 25673412)
Interacting Genes		1 interacting genes: CFTR
Entrez ID		84871
HPRD ID		07487
Ensembl ID		ENSG00000186094
Uniprot IDs		Q5VU57
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Odontogenesis Of Dentin-containing Tooth Chloride Channel Activity Multicellular Organismal-level Chemical Homeostasis Regulation Of Cellular PH Regulation Of Transmembrane Transporter Activity Membrane Docking Positive Regulation Of Exocytosis
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