DGAT2

Description		diacylglycerol O-acyltransferase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Membrane Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum Membrane
	Molecular Function	2-acylglycerol O-acyltransferase Activity Diacylglycerol O-acyltransferase Activity Protein Binding O-acyltransferase Activity Transferase Activity Acyltransferase Activity Protein Homodimerization Activity Retinol O-fatty-acyltransferase Activity
	Biological Process	Glycerol Metabolic Process Lipid Metabolic Process Monoacylglycerol Biosynthetic Process Diacylglycerol Biosynthetic Process Response To Nutrient Positive Regulation Of Triglyceride Biosynthetic Process Triglyceride Biosynthetic Process Lipid Storage Low-density Lipoprotein Particle Clearance Long-chain Fatty-acyl-CoA Metabolic Process Intracellular Triglyceride Homeostasis Retinol Metabolic Process Cholesterol Homeostasis Positive Regulation Of Gluconeogenesis Negative Regulation Of Fatty Acid Oxidation Diacylglycerol Metabolic Process Regulation Of Lipoprotein Metabolic Process Fatty Acid Homeostasis Fat Pad Development Cellular Response To Oleic Acid Regulation Of Cholesterol Metabolic Process Regulation Of Plasma Lipoprotein Particle Levels
Pathways		Acyl chain remodeling of DAG and TAG Triglyceride biosynthesis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Omega-3-carboxylic acids Fish oil
Diseases
GWAS		HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Platelet distribution width ( 32888494) Serum alkaline phosphatase levels ( 33547301)
Novel Interacting Genes		1 novel interacting genes: ELOB
Interacting Genes
Entrez ID		84649
HPRD ID		07376
Ensembl ID		ENSG00000062282
Uniprot IDs		Q96PD7
PDB IDs
Enriched GO Terms of Interacting Partners?		Target-directed MiRNA Degradation Elongin Complex VCB Complex Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing MiRNA Catabolic Process Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Regulation Of Post-transcriptional Gene Silencing MiRNA Metabolic Process Regulation Of MiRNA-mediated Gene Silencing Transcription Elongation By RNA Polymerase II Transcription Corepressor Binding Transcription Initiation At RNA Polymerase II Promoter DNA-templated Transcription Elongation DNA-templated Transcription Initiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ubiquitin Ligase Complex Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Post-transcriptional Gene Silencing Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis RNA Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process
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