ARFGAP2

Description		ARF GTPase activating protein 2
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	GTPase Activator Activity Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Transport Vesicle-mediated Transport COPI Coating Of Golgi Vesicle
Pathways		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic CDC42 GTPase cycle
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) General factor of neuroticism ( 30867560)
Novel Interacting Genes		1 novel interacting genes: TRAF6
Interacting Genes		2 interacting genes: SCGN SNCA
Entrez ID		84364
HPRD ID		06069
Ensembl ID		ENSG00000149182
Uniprot IDs		E9PN48 G5E9L0 Q8N6H7
PDB IDs		2P57
Enriched GO Terms of Interacting Partners?		Terminal Bouton Response To Desipramine Response To Interleukin-1 Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Myeloid Leukocyte Activation Regulation Of Protein Localization To Cell Periphery Regulation Of Norepinephrine Uptake Cell Cortex Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Catecholamine Metabolic Process Response To Lipopolysaccharide Interleukin-17A-mediated Signaling Pathway Response To Molecule Of Bacterial Origin Mitochondrial ATP Synthesis Coupled Electron Transport Cuprous Ion Binding Regulation Of Chaperone-mediated Autophagy Enzyme Binding Catecholamine Uptake Dopamine Uptake Response To Iron(II) Ion Dopamine Biosynthetic Process Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Cellular Respiration Supramolecular Fiber Negative Regulation Of Oxidative Phosphorylation CD40 Signaling Pathway Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD40 Receptor Complex TRIF-dependent Toll-like Receptor Signaling Pathway Protein Kinase B Binding Interleukin-33-mediated Signaling Pathway T-helper 1 Type Immune Response Interleukin-17-mediated Signaling Pathway Positive Regulation Of Neurotransmitter Secretion Regulation Of SNARE Complex Assembly Regulation Of Hydrogen Peroxide Metabolic Process
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