TMEM175

Description		transmembrane protein 175
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Endosome Membrane Membrane
	Molecular Function	Potassium Channel Activity Protein Binding Proton Channel Activity Potassium Ion Leak Channel Activity Arachidonate Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Lysosomal Lumen PH Lysosomal Lumen PH Elevation Neuron Cellular Homeostasis Potassium Ion Transmembrane Transport Phagosome-lysosome Fusion Proton Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Limited cutaneous systemic scleroderma ( 29293537) Parkinson's disease ( 25064009 34064523 32310270 32201043 31660654 28892059) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Systemic sclerosis ( 29293537) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 1 diabetes ( 34127860) Type 2 diabetes ( 25102180) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: APP GPR37
Entrez ID		84286
HPRD ID		14648
Ensembl ID		ENSG00000127419
Uniprot IDs		F6UWG6 Q9BSA9
PDB IDs		6W8N 6W8O 6W8P 6WC9 6WCA 6WCB 6WCC 7LF6 7UNL 7UNM 8DHM 8FY5 8FYF 8VIC 8VIE
Enriched GO Terms of Interacting Partners?		Dendrite Development Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Receptor Complex Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Prosaposin Receptor Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Locomotion Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Positive Regulation Of MAPK Cascade NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Positive Regulation Of Dopamine Metabolic Process Dendrite Axon Choice Point Recognition Neuron Projection Development Locomotion Involved In Locomotory Behavior Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Dopamine Biosynthetic Process Antifungal Humoral Response Nuclear Envelope Lumen
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