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HIST1H4B
Gene Name
histone cluster 1, H4b
Image
Gene Ontology Annotations
Cellular Component
Nuclear Chromosome
Nucleosome
Extracellular Region
Nucleus
Nucleoplasm
Membrane
Protein Complex
Extracellular Vesicular Exosome
Molecular Function
DNA Binding
Protein Binding
Histone Demethylase Activity (H4-K20 Specific)
Poly(A) RNA Binding
Protein Heterodimerization Activity
Biological Process
Chromatin Silencing At RDNA
Mitotic Cell Cycle
Telomere Maintenance
Chromatin Organization
Nucleosome Assembly
DNA Replication-dependent Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Gene Expression
DNA Methylation On Cytosine
CENP-A Containing Nucleosome Assembly
Histone H4-K20 Demethylation
Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Pathways
RNA Polymerase I Chain Elongation
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Mitotic Prophase
PKMTs methylate histone lysines
Regulatory RNA pathways
RNA Polymerase I Promoter Clearance
Deposition of new CENPA-containing nucleosomes at the centromere
HDMs demethylate histones
Cellular Senescence
Signaling by Wnt
HATs acetylate histones
M Phase
Amyloids
NoRC negatively regulates rRNA expression
Packaging Of Telomere Ends
Telomere Maintenance
Nucleosome assembly
RNF mutants show enhanced WNT signaling and proliferation
XAV939 inhibits tankyrase, stabilizing AXIN
DNA methylation
Transcriptional regulation by small RNAs
Meiotic recombination
DNA Damage/Telomere Stress Induced Senescence
Chromosome Maintenance
HDACs deacetylate histones
Chromatin organization
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
RNA Polymerase I Transcription
formation of the beta-catenin:TCF transactivating complex
Meiotic synapsis
Epigenetic regulation of gene expression
Senescence-Associated Secretory Phenotype (SASP)
Negative epigenetic regulation of rRNA expression
PRC2 methylates histones and DNA
Cell Cycle, Mitotic
RMTs methylate histone arginines
Chromatin modifying enzymes
Oxidative Stress Induced Senescence
TCF dependent signaling in response to WNT
RNA Polymerase I Promoter Opening
SIRT1 negatively regulates rRNA Expression
Signaling by WNT in cancer
Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-protein Interactions
2 interactors:
TERF2IP
UCHL5
Entrez ID
8366
HPRD ID
11920
Ensembl ID
ENSG00000124529
Uniprot IDs
B2R4R0
P62805
PDB IDs
2BQZ
2CV5
2KWN
2KWO
2LVM
2QQS
2RNY
2RS9
3A6N
3AFA
3AN2
3AV1
3AV2
3AYW
3AZE
3AZF
3AZG
3AZH
3AZI
3AZJ
3AZK
3AZL
3AZM
3AZN
3CFS
3CFV
3F9W
3F9X
3F9Y
3F9Z
3NQJ
3NQU
3O36
3QZS
3QZT
3QZV
3R45
3UVW
3UVX
3UVY
3UW9
3W96
3W97
3W98
3W99
4GQB
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
Enriched GO Terms of Interacting Partners
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Negative Regulation Of DNA Recombination At Telomere
Protection From Non-homologous End Joining At Telomere
Telomere Capping
Protein Localization To Chromosome, Telomeric Region
Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Regulation Of Double-strand Break Repair Via Homologous Recombination
Cellular Response To DNA Damage Stimulus
Regulation Of Telomere Maintenance
RNA-dependent DNA Replication
Forebrain Morphogenesis
Negative Regulation Of DNA Recombination
Lateral Ventricle Development
DNA Metabolic Process
Regulation Of Double-strand Break Repair
Protein Localization To Chromosome
Telomere Maintenance Via Telomere Lengthening
Brain Morphogenesis
Ventricular System Development
Cellular Response To Stress
Regulation Of DNA Repair
Regulation Of DNA Recombination
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Telomere Maintenance
Midbrain Development
Negative Regulation Of Chromosome Organization
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of DNA Metabolic Process
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Protein Deubiquitination
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Transcription, DNA-templated
Protein Modification By Small Protein Removal
RNA Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Response To DNA Damage Stimulus
Transforming Growth Factor Beta Receptor Signaling Pathway
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