HIST1H4C

Gene Name		histone cluster 1, H4c
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Binding Histone Demethylase Activity (H4-K20 Specific) Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Silencing At RDNA Mitotic Cell Cycle Telomere Maintenance Chromatin Organization Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Gene Expression DNA Methylation On Cytosine CENP-A Containing Nucleosome Assembly Histone H4-K20 Demethylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance Deposition of new CENPA-containing nucleosomes at the centromere HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression Packaging Of Telomere Ends Telomere Maintenance Nucleosome assembly RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Meiotic synapsis Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)
Protein-protein Interactions		2 interactors: PARP1 UCHL5
Entrez ID		8364
HPRD ID		11918
Ensembl ID
Uniprot IDs		B2R4R0 P62805
PDB IDs		2BQZ 2CV5 2KWN 2KWO 2LVM 2QQS 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3NQJ 3NQU 3O36 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA
Enriched GO Terms of Interacting Partners?		Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Growth Rate Protein Poly-ADP-ribosylation Cellular Response To Growth Factor Stimulus DNA Repair Response To Growth Factor DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Transcription Regulatory Region DNA Binding Protein Autoprocessing Positive Regulation Of SMAD Protein Import Into Nucleus Cellular Response To DNA Damage Stimulus Regulation Of SMAD Protein Import Into Nucleus Enzyme Linked Receptor Protein Signaling Pathway Macrophage Differentiation Forebrain Morphogenesis Cellular Response To Superoxide Lateral Ventricle Development Regulation Of Transcription Regulatory Region DNA Binding DNA Metabolic Process Response To Superoxide Protein ADP-ribosylation Response To Oxygen Radical Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of DNA Binding Brain Morphogenesis Ventricular System Development Cellular Response To Stress Base-excision Repair Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Organic Substance Telomere Maintenance Midbrain Development Regulation Of DNA Binding Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Import Into Nucleus Cellular Response To Reactive Oxygen Species Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Deubiquitination Negative Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Transcription, DNA-templated Myeloid Leukocyte Differentiation Positive Regulation Of Binding Protein Modification By Small Protein Removal RNA Biosynthetic Process
Tagcloud ?		arnt ccng1 ccng2 chance clustered clustering cyclins distinguishes distinguishing etoposide germline hierarchical leukemogenesis leukemogenic likelihood lymphoblastic maz microarrays myb oncogenes overrepresented pax permutation predisposition probe protocols pu sets went