HIST1H3B

Gene Name		histone cluster 1, H3b
Image
Gene Ontology Annotations	Cellular Component	Nuclear Chromosome Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein Complex Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Silencing At RDNA Chromatin Organization DNA Replication-dependent Nucleosome Assembly Blood Coagulation Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing
Pathways		RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase PKMTs methylate histone lysines Regulatory RNA pathways RNA Polymerase I Promoter Clearance HDMs demethylate histones Cellular Senescence Signaling by Wnt HATs acetylate histones M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination HDACs deacetylate histones Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic RMTs methylate histone arginines Chromatin modifying enzymes Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: PHF1 TRIM24 UHRF1
Entrez ID		8358
HPRD ID		11913
Ensembl ID		ENSG00000124693
Uniprot IDs		P68431
PDB IDs		1CS9 1CT6 1Q3L 2B2T 2B2U 2B2V 2B2W 2C1J 2C1N 2CV5 2KWJ 2KWK 2L75 2LBM 2M0O 2RI7 2UXN 3A1B 3AFA 3AVR 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3B95 3KMT 3KQI 3LQI 3LQJ 3O34 3O35 3O37 3RIG 3RIY 3U4S 3U5N 3U5O 3U5P 3UEE 3UEF 3UIG 3UII 3UIK 3V43 3W96 3W97 3W98 3W99 3ZG6 3ZVY 4A0J 4A0N 4A7J 4BD3 4F4U 4F56 4FWF 4HON 4I51
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Negative Regulation Of Histone H3-K27 Methylation Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Maintenance Of DNA Methylation Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Histone H3-K27 Methylation DNA Methylation On Cytosine Regulation Of Histone H3-K27 Methylation Protein Ubiquitination Chromatin Modification Protein Modification By Small Protein Conjugation Protein Catabolic Process Negative Regulation Of Histone Methylation RNA Metabolic Process Histone Monoubiquitination Chromatin Organization Positive Regulation Of Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Cellular Response To Estrogen Stimulus Cellular Response To DNA Damage Stimulus Positive Regulation Of ATPase Activity Macromolecule Biosynthetic Process Histone Ubiquitination Positive Regulation Of Histone Methylation Regulation Of ATPase Activity Protein Monoubiquitination Chromosome Organization Protein Autoubiquitination Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Histone Methylation Nucleobase-containing Compound Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process DNA Methylation Positive Regulation Of Protein Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?		36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3f3a h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies