KATNAL2

Description		katanin catalytic subunit A1 like 2
Image		No pdb structure
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Spindle Cytoskeleton Microtubule Katanin Complex Microtubule Cytoskeleton
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Microtubule Binding Microtubule Severing ATPase Activity Isomerase Activity ATP Hydrolysis Activity
	Biological Process	Meiotic Spindle Organization Cytoplasmic Microtubule Organization Microtubule Severing
Pathways
Drugs
Diseases
GWAS		Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Conscientiousness ( 21173776) Femur bone mineral density x serum urate levels interaction ( 34046847) Fruit consumption ( 32066663)
Interacting Genes		3 interacting genes: ACTN2 LNX1 UBC
Entrez ID		83473
HPRD ID		13754
Ensembl ID		ENSG00000167216
Uniprot IDs		K7EIJ8 K7EPQ6 Q8IYT4
PDB IDs
Enriched GO Terms of Interacting Partners?		Postsynaptic Cytoskeleton Organization Positive Regulation Of Endocytic Recycling Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Angiotensin-activated Signaling Pathway Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Actin Filament Depolymerization Regulation Of Endocytic Recycling Postsynaptic Actin Cytoskeleton Titin Binding Postsynaptic Density, Intracellular Component Channel Activator Activity Postsynaptic Actin Cytoskeleton Organization Positive Regulation Of Protein Depolymerization Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Cell Junction Organization Pseudopodium LIM Domain Binding Protein Ubiquitination Modification-dependent Protein Catabolic Process Protein Tag Activity Synapse Maturation Positive Regulation Of Cation Channel Activity Focal Adhesion Assembly Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Potassium Ion Transport Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Regulation Of Protein Localization To Cell Surface Cell-substrate Junction Organization Positive Regulation Of Protein-containing Complex Disassembly Cell-substrate Junction Assembly Positive Regulation Of Transporter Activity Cardiac Muscle Cell Development Sarcomere Organization Post-translational Protein Modification Structural Constituent Of Muscle Cardiac Cell Development Hippocampal Mossy Fiber To CA3 Synapse Regulation Of Actin Filament Depolymerization Sarcomere Cortical Actin Cytoskeleton Macromolecule Catabolic Process Platelet Alpha Granule Lumen
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