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H2BC7
Description
H2B clustered histone 7
Image
GO Annotations
Cellular Component
Nucleosome
Extracellular Space
Nucleus
Nucleoplasm
Chromosome
Cytosol
Extracellular Exosome
Molecular Function
DNA Binding
Protein Binding
Structural Constituent Of Chromatin
Identical Protein Binding
Protein Heterodimerization Activity
Biological Process
Innate Immune Response In Mucosa
Nucleosome Assembly
Antibacterial Humoral Response
Defense Response To Bacterium
Defense Response To Gram-positive Bacterium
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Ub-specific processing proteases
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Deposition of new CENPA-containing nucleosomes at the centromere
Assembly of the ORC complex at the origin of replication
G2/M DNA damage checkpoint
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Defective pyroptosis
Negative Regulation of CDH1 Gene Transcription
Amyloid fiber formation
Chromatin modifications during the maternal to zygotic transition (MZT)
Replacement of protamines by nucleosomes in the male pronucleus
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by KRAB-ZFP proteins
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Regulation of PD-L1(CD274) transcription
Drugs
Copper
Diseases
GWAS
Interacting Genes
3 interacting genes:
AP2M1
CFTR
ESR1
Entrez ID
8343
HPRD ID
11900
Ensembl ID
ENSG00000277224
Uniprot IDs
B2R4S9
P62807
PDB IDs
5GT0
5KGF
6ACO
6C0W
6FML
6R0C
6RNY
6SE0
6SE6
6SEE
6SEF
6SEG
6UPK
6UPL
6X59
6X5A
6XJD
7A08
7JO9
7JOA
7PII
7R5R
7TAN
7TRF
7U46
7U47
7U4D
7U50
7U51
7U52
7U53
7UV9
7Y8R
7YWX
7YYH
8ATF
8AV6
8JBX
8OFF
8OO7
8OOA
8OOP
8OOS
8OX0
8OX1
8QZM
8TXV
8TXW
8TXX
8U13
8VWS
8VWT
8VWU
8VWV
8X15
8X19
8X1C
9DWF
9DWG
9DWH
9DWI
9DWJ
9DWK
9DWL
9DWM
9EOZ
Enriched GO Terms of Interacting Partners
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14-3-3 Protein Binding
Clathrin-coated Endocytic Vesicle Membrane
Bicarbonate Transmembrane Transporter Activity
Intracellular PH Elevation
Positive Regulation Of Tooth Mineralization
Lysosomal Membrane
Chloride Channel Inhibitor Activity
Positive Regulation Of Anion Channel Activity
Positive Regulation Of Enamel Mineralization
Transepithelial Water Transport
Steroid Metabolic Process
Chloride Channel Regulator Activity
Intracellularly ATP-gated Chloride Channel Activity
Positive Regulation Of Voltage-gated Chloride Channel Activity
Sec61 Translocon Complex Binding
Regulation Of Enamel Mineralization
Positive Regulation Of Monoatomic Anion Transport
Membrane Hyperpolarization
Positive Regulation Of Synaptic Vesicle Endocytosis
Positive Regulation Of Synaptic Vesicle Recycling
Lipid Binding
Postsynaptic Neurotransmitter Receptor Internalization
Signal Sequence Binding
Extrinsic Component Of Presynaptic Endocytic Zone Membrane
Nuclear Estrogen Receptor Activity
Regulation Of Branching Involved In Prostate Gland Morphogenesis
TFIIB-class Transcription Factor Binding
Prostate Epithelial Cord Elongation
Nitric-oxide Synthase Regulator Activity
Positive Regulation Of Nitric-oxide Synthase Activity
Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis
Mammary Gland Branching Involved In Pregnancy
Antral Ovarian Follicle Growth
Regulation Of Nitric-oxide Synthase Activity
Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation
Enzyme Binding
Amelogenesis
ATPase-coupled Inorganic Anion Transmembrane Transporter Activity
Prostate Gland Growth
Vagina Development
AP-2 Adaptor Complex
Estrogen Response Element Binding
Cellular Response To Lipid
Clathrin Adaptor Complex
Branching Involved In Prostate Gland Morphogenesis
Regulation Of Monoatomic Anion Transport
Epithelial Fluid Transport
Branch Elongation Of An Epithelium
Golgi-associated Vesicle Membrane
Cellular Response To Forskolin
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