KIF18A

Description		kinesin family member 18A
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GO Annotations	Cellular Component	Kinetochore Ruffle Nucleus Cytoplasm Centrosome Kinetochore Microtubule Cytosol Cytoskeleton Kinesin Complex Microtubule Spindle Microtubule Caveola Microtubule Cytoskeleton Cell Projection Mitotic Spindle Astral Microtubule Mitotic Spindle Midzone
	Molecular Function	Nucleotide Binding Cytoskeletal Motor Activity Microtubule Motor Activity Actin Binding Protein Binding ATP Binding Microtubule Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Microtubule Plus-end Binding Tubulin-dependent ATPase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Microtubule-based Movement Microtubule Depolymerization Mitotic Metaphase Chromosome Alignment Male Meiotic Nuclear Division Protein Transport Regulation Of Microtubule Cytoskeleton Organization Cellular Response To Estradiol Stimulus Seminiferous Tubule Development
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins Kinesins
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Chloride levels ( 29403010) Fulminant type 1 diabetes ( 30552108) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: CDC20 PPP1CA
Entrez ID		81930
HPRD ID		11177
Ensembl ID		ENSG00000121621
Uniprot IDs		Q8NI77
PDB IDs		3LRE 5OAM 5OCU 5OGC 7RSI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Synaptic Plasticity Meiotic Cell Cycle Phase Transition Mitotic Checkpoint Complex Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Chromosome Organization Positive Regulation Of Synapse Maturation Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Metaphase/anaphase Transition Of Cell Cycle Metaphase/anaphase Transition Of Meiosis I RNA Polymerase II Promoter Clearance Regulation Of Glycogen Catabolic Process Positive Regulation Of Termination Of DNA-templated Transcription Glycogen Granule Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Termination Of RNA Polymerase II Transcription PTW/PP1 Phosphatase Complex Double-strand Break Repair Via Alternative Nonhomologous End Joining RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Ubiquitin Ligase Activator Activity Positive Regulation Of Ubiquitin-protein Transferase Activity Telomere Maintenance In Response To DNA Damage Protein Phosphatase Type 1 Complex Mitotic Sister Chromatid Cohesion Positive Regulation Of Mitotic Metaphase/anaphase Transition Transition Metal Ion Binding Cadherin Binding Involved In Cell-cell Adhesion Positive Regulation Of Glycogen Biosynthetic Process Response To Lead Ion Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Sister Chromatid Separation Anaphase-promoting Complex Entrainment Of Circadian Clock By Photoperiod Regulation Of Translation In Response To Stress Negative Regulation Of Transcription Elongation By RNA Polymerase II Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Meiotic Nuclear Division Positive Regulation Of Chromosome Separation Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Synapse Maturation Protein Phosphatase 1 Binding Photoperiodism Regulation Of Glycogen Biosynthetic Process Entrainment Of Circadian Clock
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