COL21A1

Description		collagen type XXI alpha 1 chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Cytoplasm Endoplasmic Reticulum Lumen Cytosol Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process
Pathways		Collagen biosynthesis and modifying enzymes Collagen chain trimerization
Drugs
Diseases
GWAS		Allergic sensitization ( 23817571) Body size at age 10 ( 32376654) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 30578418) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Gut microbiota (functional units) ( 27694959) Heel bone mineral density ( 30598549) Joint mobility (Beighton score) ( 27182965) Psychosis (atypical) ( 24132900) Pulse pressure ( 27618447 27618448 27841878 30578418) Schizophrenia ( 30285260) Small cell lung carcinoma ( 28604730) Systolic blood pressure ( 30578418)
Interacting Genes		1 interacting genes: CFTR
Entrez ID		81578
HPRD ID		09884
Ensembl ID		ENSG00000124749
Uniprot IDs		A0A158RFW1 B3KU30 B7ZLK3 Q96P44
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Golgi-associated Vesicle Membrane Cellular Response To Forskolin Response To Forskolin Chloride Transmembrane Transporter Activity Sperm Capacitation Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Odontogenesis Of Dentin-containing Tooth Chloride Channel Activity Multicellular Organismal-level Chemical Homeostasis Regulation Of Cellular PH Regulation Of Transmembrane Transporter Activity Membrane Docking Positive Regulation Of Exocytosis
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