CPEB4

Description		cytoplasmic polyadenylation element binding protein 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Postsynaptic Density Axon Dendrite Growth Cone Cell Projection Neuron Projection Dendritic Spine Synapse Perinuclear Region Of Cytoplasm Postsynapse
	Molecular Function	MRNA Regulatory Element Binding Translation Repressor Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Factor Activity, RNA Binding Ribosome Binding Translation Regulator Activity Metal Ion Binding
	Biological Process	Response To Ischemia Translation Regulation Of Translation Ionotropic Glutamate Receptor Signaling Pathway Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation Negative Regulation Of Neuron Apoptotic Process Cellular Response To Amino Acid Stimulus Negative Regulation Of Cytoplasmic Translation
Pathways
Drugs
Diseases
GWAS		A body shape index ( 34021172) Body mass index ( 28892062) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 23128233) Diastolic blood pressure ( 27841878 28135244) Emotional recognition ( 31596458) Eosinophil count ( 32888494) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Mean corpuscular hemoglobin ( 27863252 29403010) Mean corpuscular volume ( 27863252 29403010) Metabolite levels ( 23823483) Mosquito bite size ( 28199695) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Obesity-related traits ( 23251661) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494) Risk-taking tendency (4-domain principal component model) ( 30643258) Sjögren's syndrome ( 24097067) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-hip ratio and systolic blood pressure (pairwise) ( 33619380) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		1 interacting genes: FBXO7
Entrez ID		80315
HPRD ID		16746
Ensembl ID		ENSG00000113742
Uniprot IDs		B7ZLQ8 E5RFP2 Q17RY0
PDB IDs		2MKI 2MKJ 5DIF
Enriched GO Terms of Interacting Partners?		Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting To Mitochondrion Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitophagy Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Autophagy Of Mitochondrion Autophagy Of Mitochondrion SCF Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex Positive Regulation Of Macroautophagy Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Ubiquitin Binding Negative Regulation Of Hemopoiesis Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Autophagy Negative Regulation Of Neuron Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cell Activation Protein Targeting Regulation Of Lymphocyte Differentiation Negative Regulation Of Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Macroautophagy Negative Regulation Of Leukocyte Activation Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Neuron Apoptotic Process Lymphocyte Differentiation Ubiquitin-protein Transferase Activity
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