PREX2

Name	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
Structure
Interactors	4 interactors: CDC42 RAC1 RHOA TGFBR1
GO Annotations	Cellular Component	Cytosol Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Serine/threonine Kinase Inhibitor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adult Locomotory Behavior Negative Regulation Of TOR Signaling Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Dendrite Morphogenesis Regulation Of Small GTPase Mediated Signal Transduction
Pathways	Regulation of PTEN stability and activity RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
GWAS	Systolic blood pressure ( 30224653 )
Entrez ID	80243
HPRD ID	13135
Ensembl ID	ENSG00000046889
Uniprot IDs	Q70Z35
PDB IDs	6BNM
GO Terms Enriched among Interactors ?	Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Stress Fiber Assembly Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Actin Filament Organization Membrane Invagination Non-canonical Wnt Signaling Pathway Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process G Protein Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Locomotion Thioesterase Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Establishment Or Maintenance Of Cell Polarity Cell-cell Junction Organization Establishment Of Epithelial Cell Apical/basal Polarity Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-substrate Adhesion Establishment Of Apical/basal Cell Polarity Postsynapse Regulation Of Cell Migration Polarized Epithelial Cell Differentiation Regulation Of Cell Projection Assembly GTP-dependent Protein Binding Filopodium Assembly Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Motility Actin Filament Organization Small GTPase-mediated Signal Transduction Cell Motility Positive Regulation Of Lamellipodium Assembly Regulation Of Locomotion Wnt Signaling Pathway Establishment Of Epithelial Cell Polarity Positive Regulation Of Filopodium Assembly Cerebral Cortex Cell Migration Phagocytosis, Engulfment