TASL

Description		TLR adaptor interacting with endolysosomal SLC15A4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Endosome Cytosol Endosome Membrane Membrane Endolysosome Membrane
	Molecular Function	Protein Binding
	Biological Process	Immune System Process Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Regulation Of Lysosomal Lumen PH Innate Immune Response Positive Regulation Of Innate Immune Response
Pathways		SLC15A4:TASL-dependent IRF5 activation
Drugs
Diseases
GWAS
Interacting Genes		2 interacting genes: CFTR CRYAA
Entrez ID		80231
HPRD ID		06518
Ensembl ID		ENSG00000120280
Uniprot IDs		Q9HAI6
PDB IDs		8JZU 8WX5
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Bicarbonate Transmembrane Transporter Activity Regulation Of Cellular Localization Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Animal Organ Morphogenesis Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Lens Fiber Cell Morphogenesis Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Tubulin Complex Assembly Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport Response To UV-A Golgi-associated Vesicle Membrane Lens Morphogenesis In Camera-type Eye Cellular Response To Forskolin Embryonic Camera-type Eye Morphogenesis Response To Forskolin Protein-containing Complex Chloride Transmembrane Transporter Activity Sperm Capacitation Structural Constituent Of Eye Lens Apoptotic Process Involved In Morphogenesis Bicarbonate Transport Water Transport Embryonic Eye Morphogenesis Protein Refolding Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Apoptotic Process Involved In Development Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Lens Development In Camera-type Eye
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