OPA3

Description		outer mitochondrial membrane lipid metabolism regulator OPA3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion
	Molecular Function
	Biological Process	Mitochondrion Organization Visual Perception Regulation Of Lipid Metabolic Process Regulation Of Growth Fat Cell Differentiation Neuromuscular Process Bone Development
Pathways
Drugs
Diseases		Autosomal dominant optic atrophy (DOA); Kjer's optic neuropathy 3-Methylglutaconic aciduria (MGCA)
GWAS		Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Depression and alcohol dependence ( 22064162)
Novel Interacting Genes		1 novel interacting genes: NGLY1
Interacting Genes		5 interacting genes: APP KDM1A PRMT6 SUV39H1 UBC
Entrez ID		80207
HPRD ID		05956
Ensembl ID		ENSG00000125741
Uniprot IDs		B4DK77 Q9H6K4
PDB IDs
Enriched GO Terms of Interacting Partners?		Chromatin Binding Chromatin Remodeling Histone H3 Methyltransferase Activity Neuron Maturation Chromatin Organization Epigenetic Regulation Of Gene Expression Histone Methyltransferase Activity Negative Regulation Of Transcription By RNA Polymerase II Cellular Response To CAMP Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Multicellular Organism Growth Amylin Binding Positive Regulation Of Toll Signaling Pathway Histone H2AR3 Methyltransferase Activity Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Response To CAMP Acetylcholine Receptor Activator Activity PTB Domain Binding Response To Purine-containing Compound Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Endothelin Production Negative Regulation Of RNA Metabolic Process Growth Cone Filopodium Macromolecule Metabolic Process Lipoprotein Particle Regulation Of Cellular Response To Stress Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization ENoSc Complex Telomeric Repeat-containing RNA Binding Regulation Of Signal Transduction By P53 Class Mediator FAD-dependent H3K4me/H3K4me3 Demethylase Activity Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Histone H3R2 Methyltransferase Activity Histone Arginine N-methyltransferase Activity Cell Maturation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling
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