UXS1

Description		UDP-glucuronate decarboxylase 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Golgi Apparatus Membrane Golgi Cisterna Membrane Extracellular Exosome Catalytic Complex
	Molecular Function	Lyase Activity Carboxy-lyase Activity Identical Protein Binding Protein Homodimerization Activity UDP-glucuronate Decarboxylase Activity NAD+ Binding
	Biological Process	UDP-D-xylose Biosynthetic Process D-xylose Metabolic Process
Pathways		Formation of the active cofactor, UDP-glucuronate Glycosaminoglycan-protein linkage region biosynthesis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Hip circumference adjusted for BMI ( 34021172) Pursuit maintenance gain ( 29064472) Pursuit maintenance gain in psychotic disorders ( 29064472) Right lateral prefrontal cortical growth ( 29682794)
Interacting Genes		3 interacting genes: AKT1 FBXO7 FXR1
Entrez ID		80146
HPRD ID		15642
Ensembl ID		ENSG00000115652
Uniprot IDs		B3KV61 Q8NBZ7
PDB IDs		2B69 4GLL 4LK3 4M55
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Catabolic Process Establishment Of Protein Localization To Mitochondrion Translational Initiation Negative Regulation Of RNA Catabolic Process Regulation Of Cell Development Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of TRNA Methylation Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Positive Regulation Of Protein Localization To Endoplasmic Reticulum Regulation Of MRNA Stability Germ Cell Development Postsynapse Response To Insulin-like Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle Mammalian Oogenesis Stage Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Translation TRNA (guanine-N7)-methylation Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Multicellular Organismal Development Regulation Of RNA Stability Regulation Of Macroautophagy Cellular Response To Rapamycin Positive Regulation Of Translation Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Lysosome Positive Regulation Of Endodeoxyribonuclease Activity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Lewy Body Core Regulation Of Neuron Apoptotic Process Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane TORC2 Complex Binding Positive Regulation Of Deoxyribonuclease Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process SREBP-SCAP Complex Retention In Endoplasmic Reticulum Regulation Of Cell Differentiation Negative Regulation Of SREBP Signaling Pathway Negative Regulation Of Fatty Acid Beta-oxidation Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Protein Polyubiquitination Maintenance Of Protein Location In Mitochondrion
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