DOCK5

Description		dedicator of cytokinesis 5
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GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Plasma Membrane Membrane Cell Projection Anchoring Junction
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Small GTPase-mediated Signal Transduction Myoblast Fusion Positive Regulation Of Epithelial Cell Migration Cell Migration Rac Protein Signal Transduction Bone Remodeling Podosome Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		RAC1 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Femur bone mineral density x serum urate levels interaction ( 34046847) Glucose homeostasis traits ( 25524916) Heel bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Length of menstrual cycle ( 30202859) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) QT interval ( 29213071) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		2 interacting genes: ATXN1 CRK
Entrez ID		80005
HPRD ID		09925
Ensembl ID		ENSG00000147459
Uniprot IDs		B9A015 Q9H7D0
PDB IDs		7DPA 8JHK 8XM7 8ZJ2 8ZJI 8ZJJ 8ZJK 8ZJL 8ZJM
Enriched GO Terms of Interacting Partners?		Helper T Cell Diapedesis Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Diapedesis Cerebellar Neuron Development Protein Phosphorylated Amino Acid Binding Positive Regulation Of Receptor Clustering Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Reelin-mediated Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Response To Endothelin Cellular Response To Endothelin Response To Cholecystokinin Postsynaptic Specialization Assembly Poly(G) Binding POZ Domain Binding Nuclear Inclusion Body Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Hepatocyte Growth Factor Cellular Response To Nitric Oxide Protein-containing Complex Regulation Of Receptor Clustering Insulin-like Growth Factor Receptor Binding Cellular Response To Reactive Nitrogen Species Response To Yeast Positive Regulation Of Rac Protein Signal Transduction Response To Nitric Oxide Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Postsynaptic Specialization Organization Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Ephrin Receptor Binding Signaling Receptor Complex Adaptor Activity Regulation Of Rac Protein Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway T Cell Migration Response To Nerve Growth Factor Dendrite Development SH2 Domain Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Central Nervous System Neuron Development Protein Tyrosine Kinase Binding Positive Regulation Of Smooth Muscle Cell Migration Cellular Response To Nerve Growth Factor Stimulus Regulation Of Glial Cell Proliferation Phosphotyrosine Residue Binding Lung Alveolus Development Regulation Of Cell Adhesion Mediated By Integrin
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