NEK11

Description		NIMA related kinase 11
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Mitotic Intra-S DNA Damage Checkpoint Signaling Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Drugs		Dabrafenib Fostamatinib
Diseases
GWAS		Carotid intima media thickness ( 26343869) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Hippocampal sclerosis ( 25188341) Obsessive-compulsive traits ( 33531474) Phenylephrine infusion rate during anesthesia ( 31455332) Weight ( 28552196)
Novel Interacting Genes		1 novel interacting genes: ACAD11
Interacting Genes		5 interacting genes: APP BLM MFHAS1 MYC NEK2
Entrez ID		79858
HPRD ID		14821
Ensembl ID		ENSG00000114670
Uniprot IDs		B4DDN2 B4DM56 E9PHI8 Q8NG66
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Division Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Regulation Of MiRNA Transcription Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein-containing Complex Response To Radiation Regulation Of Cell Cycle Chromosome Organization Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Telomere Maintenance Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Negative Regulation Of Centriole-centriole Cohesion Regulation Of MiRNA Metabolic Process Response To Alkaloid Regulation Of DNA Metabolic Process Positive Regulation Of JNK Cascade Regulation Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Regulation Of MAPK Cascade 8-hydroxy-2'-deoxyguanosine DNA Binding Forked DNA-dependent Helicase Activity Telomeric G-quadruplex DNA Binding DNA/DNA Annealing Activity NK T Cell Proliferation Myc-Max Complex Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Acinar Cell Proliferation Regulation Of Centriole-centriole Cohesion Medium-chain Fatty Acyl-CoA Dehydrogenase Activity
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