PEAK1

Description		pseudopodium enriched atypical kinase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Actin Cytoskeleton Anchoring Junction
	Molecular Function	Protein Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	Cell Migration Substrate Adhesion-dependent Cell Spreading Protein Autophosphorylation Focal Adhesion Assembly Regulation Of Focal Adhesion Assembly Regulation Of Cell Motility
Pathways		RHOU GTPase cycle RHOV GTPase cycle
Drugs
Diseases
GWAS		Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: MTNR1B
Entrez ID		79834
HPRD ID		13911
Ensembl ID		ENSG00000173517
Uniprot IDs		Q9H792
PDB IDs		6BHC 8DGM
Enriched GO Terms of Interacting Partners?		Melatonin Receptor Activity Positive Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of CGMP-mediated Signaling Regulation Of Neuronal Action Potential Negative Regulation Of Transmission Of Nerve Impulse Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Vasoconstriction Regulation Of CGMP-mediated Signaling Positive Regulation Of Circadian Rhythm Negative Regulation Of Nervous System Process Regulation Of Transmission Of Nerve Impulse Negative Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Circadian Sleep/wake Cycle Positive Regulation Of Behavior Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Action Potential Regulation Of Vasoconstriction Negative Regulation Of Hormone Secretion Negative Regulation Of Protein Secretion Regulation Of Behavior Camera-type Eye Development Regulation Of Circadian Rhythm Eye Development Negative Regulation Of Protein Transport Regulation Of Nervous System Process Negative Regulation Of Establishment Of Protein Localization Blood Vessel Diameter Maintenance Negative Regulation Of Secretion By Cell Regulation Of Tube Size Regulation Of Insulin Secretion Negative Regulation Of Secretion Sensory Organ Development Negative Regulation Of Neuron Apoptotic Process Carbohydrate Homeostasis Regulation Of Peptide Hormone Secretion Glucose Homeostasis Negative Regulation Of Protein Localization Regulation Of Blood Circulation Regulation Of Hormone Secretion Regulation Of Protein Secretion Vascular Process In Circulatory System Regulation Of Neuron Apoptotic Process Chemical Synaptic Transmission Circulatory System Process Trans-synaptic Signaling
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