METTL8

Description		methyltransferase 8, tRNA N3-cytidine
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Methyltransferase Activity RNA Methyltransferase Activity MRNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity Transferase Activity TRNA (cytidine-3-)-methyltransferase Activity
	Biological Process	TRNA Processing MRNA Metabolic Process Methylation Positive Regulation Of Mitochondrial Translation Mitochondrial TRNA Modification TRNA C3-cytosine Methylation
Pathways
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Body mass index ( 25673413) Hip circumference adjusted for BMI ( 34021172) Hippocampal atrophy ( 22745009)
Interacting Genes		2 interacting genes: APP DSCR9
Entrez ID		79828
HPRD ID		07845
Ensembl ID		ENSG00000123600
Uniprot IDs		A8K7U3 B3KW44 B4DLT0 Q9H825
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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