CARF

Description		calcium responsive transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Granular Component Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Calcium Ion
Pathways
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 32469254 33020668) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Lacunar stroke ( 33773637) Migraine ( 27322543) Myocardial infarction ( 33532862) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White matter hyperintensities ( 30002152 32358547) White matter integrity (fractional anisotropy) ( 32358547)
Interacting Genes		3 interacting genes: APP CDKN2A LMO3
Entrez ID		79800
HPRD ID		10464
Ensembl ID		ENSG00000138380
Uniprot IDs		B4DIA7 C9JI92 Q8N187
PDB IDs
Enriched GO Terms of Interacting Partners?		Amyloid Fibril Formation Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Cell Differentiation Regulation Of Response To Calcium Ion Regulation Of ERK1 And ERK2 Cascade Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Developmental Process Lipoprotein Particle Regulation Of Protein Localization To Nucleus Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Senescence-associated Heterochromatin Focus Ligase Inhibitor Activity Negative Regulation Of Immature T Cell Proliferation In Thymus Apoptotic Process Involved In Mammary Gland Involution Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity
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