MANEA

Gene Name		mannosidase, endo-alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Glycoprotein Endo-alpha-1,2-mannosidase Activity
	Biological Process	Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective MAN1B1 causes MRT15 Defective ALG12 causes ALG12-CDG (CDG-1g) N-glycan trimming and elongation in the cis-Golgi Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: DNM2
Entrez ID		79694
HPRD ID		14357
Ensembl ID		ENSG00000172469
Uniprot IDs		Q5SRI9
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Membrane Tubulation Nitric Oxide Metabolic Process Reactive Nitrogen Species Metabolic Process Transferrin Transport Regulation Of Nitric-oxide Synthase Activity Receptor Internalization Regulation Of Axon Extension Regulation Of Oxidoreductase Activity Iron Ion Transport Receptor Metabolic Process Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Synaptic Vesicle Transport Reactive Oxygen Species Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Size Regulation Of Axonogenesis Establishment Of Vesicle Localization Vesicle Localization Antigen Processing And Presentation Of Peptide Antigen Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Golgi Vesicle Transport Antigen Processing And Presentation Regulation Of Developmental Growth Establishment Of Organelle Localization Regulation Of Cellular Component Size Regulation Of Cell Growth Receptor-mediated Endocytosis
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