SMC6

Description		structural maintenance of chromosomes 6
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm Chromosome PML Body Nuclear Speck Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break Mitotic Spindle Pole Chromosomal Region
	Molecular Function	Nucleotide Binding DNA Secondary Structure Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding
	Biological Process	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair DNA Recombination DNA Damage Response Protein Sumoylation Regulation Of Telomere Maintenance Host-mediated Suppression Of Viral Genome Replication Positive Regulation Of Chromosome Segregation Cellular Senescence Chromatin Looping
Pathways		SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS		LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Total cholesterol levels ( 30275531)
Interacting Genes		1 interacting genes: SLF2
Entrez ID		79677
HPRD ID		10242
Ensembl ID		ENSG00000163029
Uniprot IDs		A0A2S1ZR87 Q96SB8
PDB IDs
Enriched GO Terms of Interacting Partners?		Smc5-Smc6 Complex Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Positive Regulation Of Sister Chromatid Cohesion Regulation Of Sister Chromatid Cohesion Chromatin Looping Protein Localization To Site Of Double-strand Break Protein Sumoylation Positive Regulation Of Double-strand Break Repair Protein Localization To Chromosome Site Of Double-strand Break Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance PML Body Recombinational Repair Positive Regulation Of DNA Repair Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Chromosome, Telomeric Region Positive Regulation Of Protein-containing Complex Assembly Double-strand Break Repair Regulation Of Chromosome Organization Regulation Of DNA Repair DNA Recombination Positive Regulation Of Cell Cycle Process Positive Regulation Of DNA Metabolic Process
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