PXDN

Description		peroxidasin
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Cell Surface Extracellular Matrix Extracellular Exosome
	Molecular Function	Peroxidase Activity Interleukin-1 Receptor Antagonist Activity Extracellular Matrix Structural Constituent Oxidoreductase Activity Oxidoreductase Activity, Acting On Peroxide As Acceptor Heme Binding Laminin-1 Binding Metal Ion Binding Lactoperoxidase Activity
	Biological Process	Angiogenesis Eye Development Negative Regulation Of Cytokine-mediated Signaling Pathway Immune Response Response To Oxidative Stress Cell Adhesion Extracellular Matrix Organization Collagen Fibril Organization Hydrogen Peroxide Catabolic Process System Development Protein Homooligomerization Protein Homotrimerization Basement Membrane Assembly Basement Membrane Organization Cellular Oxidant Detoxification
Pathways		Crosslinking of collagen fibrils Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Height ( 31562340) Refractive error ( 32231278) Sleep (1/3-day periodicity) ( 33075057) Systemic sclerosis ( 30247649) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		2 interacting genes: BNIPL CDC42
Entrez ID		7837
HPRD ID		18965
Ensembl ID		ENSG00000130508
Uniprot IDs		Q92626
PDB IDs
Enriched GO Terms of Interacting Partners?		Leading Edge Membrane Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Growth Endothelin Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuropilin Signaling Pathway GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Regulation Of Growth Rate Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Golgi Localization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Dendritic Cell Migration Establishment Of Monopolar Cell Polarity GTP-dependent Protein Binding Heart Contraction Cardiac Conduction System Development Embryonic Heart Tube Development Dendritic Spine Morphogenesis Establishment Of Epithelial Cell Apical/basal Polarity Filopodium Assembly Establishment Or Maintenance Of Monopolar Cell Polarity Cell Migration Involved In Heart Development Polarized Epithelial Cell Differentiation Positive Regulation Of Lamellipodium Assembly Spindle Midzone Nuclear Migration Establishment Of Epithelial Cell Polarity Positive Regulation Of Filopodium Assembly Nucleus Localization Heart Process Dendritic Spine Organization Phagocytosis, Engulfment Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Lamellipodium Assembly Macrophage Differentiation Neuron Projection Organization Substantia Nigra Development Regulation Of Filopodium Assembly
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