UROS

Description		uroporphyrinogen III synthase
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Uroporphyrinogen-III Synthase Activity Folic Acid Binding Lyase Activity
	Biological Process	Porphyrin-containing Compound Biosynthetic Process Uroporphyrinogen III Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Tetrapyrrole Biosynthetic Process Heme O Biosynthetic Process Response To Platinum Ion Cellular Response To Arsenic-containing Substance Cellular Response To Amine Stimulus
Pathways		Heme biosynthesis
Drugs
Diseases		Erythropoietic porphyria (EP), including: Erythropoietic protoporphyria (EPP); Congenital erythropoietic porphyria (CEP); Gunther Disease; X-linked erythropoietic protoporphyria (XLEPP)
GWAS		Blood protein levels ( 30072576)
Interacting Genes		1 interacting genes: UBQLN4
Entrez ID		7390
HPRD ID		06087
Ensembl ID		ENSG00000188690
Uniprot IDs		A0A0S2Z4T8 A0A0S2Z5C5 A0A3B3ISM6 A0A3B3ITJ2 P10746 Q5T3L8
PDB IDs		1JR2
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Autophagosome Maturation Nuclear Proteasome Complex Cytosolic Proteasome Complex K48-linked Polyubiquitin Modification-dependent Protein Binding Regulation Of Autophagosome Maturation Negative Regulation Of DNA Repair Polyubiquitin Modification-dependent Protein Binding Site Of DNA Damage Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Macroautophagy Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Recombination Autophagosome Negative Regulation Of Protein-containing Complex Disassembly Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Autophagy Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein-containing Complex Disassembly Regulation Of Double-strand Break Repair Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy Regulation Of DNA Repair
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