C8G

Description		complement C8 gamma chain
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GO Annotations	Cellular Component	Extracellular Region Membrane Attack Complex Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex
	Molecular Function	Protein Binding Retinol Binding
	Biological Process	Immune System Process Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Complement Activation, GZMK Pathway
Pathways		Terminal pathway of complement Regulation of Complement cascade
Drugs		Zinc Lauric acid Citric acid Zinc acetate
Diseases		Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Keratoconus ( 33649486)
Interacting Genes		2 interacting genes: C8A UBQLN2
Entrez ID		733
HPRD ID		00407
Ensembl ID		ENSG00000176919
Uniprot IDs		P07360
PDB IDs		1IW2 1LF7 2OVA 2OVD 2OVE 2QOS 2RD7 3OJY 6H03 6H04 7NYC 7NYD 8B0F 8B0G 8B0H
Enriched GO Terms of Interacting Partners?		Membrane Attack Complex Complement Binding Other Organism Cell Membrane Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Complement Activation, Alternative Pathway Complement Activation, GZMK Pathway Transmembrane Transporter Complex Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Regulation Of ERAD Pathway Negative Regulation Of Receptor-mediated Endocytosis Complement Activation, Classical Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Autophagosome Assembly Molecular Condensate Scaffold Activity Complement Activation Regulation Of Vacuole Organization
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