DEFA1B

Description		defensin alpha 1B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding Pore-forming Activity
	Biological Process	Innate Immune Response In Mucosa Chemotaxis Defense Response Immune Response T Cell Chemotaxis Antibacterial Humoral Response Estrogen Receptor Signaling Pathway Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Protozoan Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Defense Response To Virus Disruption Of Plasma Membrane Integrity In Another Organism Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Defensins Alpha-defensins Neutrophil degranulation
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Dental caries (decayed and filled deciduous teeth) ( 31533690) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)
Interacting Genes		1 interacting genes: UBQLN2
Entrez ID		728358
HPRD ID		19030
Ensembl ID		ENSG00000240247
Uniprot IDs		P59665
PDB IDs		2KHT 2PM1 3GNY 3H6C 3HJ2 3HJD 3LO1 3LO2 3LO4 3LO6 3LO9 3LOE 3LVX 4DU0 4LB1 4LB7 4LBB 4LBF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERAD Pathway Negative Regulation Of Receptor Internalization Regulation Of Clathrin-dependent Endocytosis Regulation Of ERAD Pathway Negative Regulation Of Receptor-mediated Endocytosis Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Autophagosome Assembly Molecular Condensate Scaffold Activity Regulation Of Vacuole Organization Negative Regulation Of Endocytosis Autophagosome Regulation Of Receptor Internalization Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Autophagosome Organization Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of G Protein-coupled Receptor Signaling Pathway Vacuole Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Macroautophagy Response To Endoplasmic Reticulum Stress Regulation Of Organelle Assembly
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