D2HGDH

Description		D-2-hydroxyglutarate dehydrogenase
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix
	Molecular Function	Catalytic Activity Zinc Ion Binding Oxidoreductase Activity Metal Ion Binding Flavin Adenine Dinucleotide Binding (R)-2-hydroxyglutarate Dehydrogenase Activity FAD Binding
	Biological Process	Lactate Metabolic Process 2-oxoglutarate Metabolic Process Malate Metabolic Process Response To Manganese Ion Response To Zinc Ion Response To Cobalt Ion Response To Magnesium Ion Response To Calcium Ion Tartrate Metabolic Process
Pathways		Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Drugs
Diseases
GWAS		Adult diffuse glioma (IDH mutation) ( 32386320) Adult diffuse glioma (IDH mutation, 1p/19q non-codeleted) ( 32386320) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergy ( 27182965) Artificially sweetened beverage consumption ( 31046077) Asthma ( 27182965 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Eczema ( 31361310) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Medication use (adrenergics, inhalants) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Medication use (glucocorticoids) ( 31015401) Neutrophil percentage of granulocytes ( 27863252) Serum cancer antigen 125 (CA 125) levels ( 31666285) Serum metabolite levels ( 33031748) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		1 interacting genes: STK11
Entrez ID		728294
HPRD ID
Ensembl ID		ENSG00000180902
Uniprot IDs		B3KSR6 B4E3K7 B5MCV2 Q8N465
PDB IDs		6LPN 6LPP 6LPQ 6LPT 6LPU 6LPX
Enriched GO Terms of Interacting Partners?		Positive T Cell Selection LRR Domain Binding Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Intracellular Protein-containing Complex Cellular Response To UV-B Positive Thymic T Cell Selection Golgi Localization Dendrite Extension Positive Regulation Of Vesicle Transport Along Microtubule Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Epithelial Cell Proliferation Involved In Prostate Gland Development Anoikis G1 To G0 Transition Response To UV-B Thymic T Cell Selection Peptidyl-threonine Phosphorylation Serine/threonine Protein Kinase Complex T Cell Selection Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Protein Kinase Activator Activity Negative Regulation Of Cold-induced Thermogenesis Regulation Of Microtubule-based Movement Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Vasculature Development Regulation Of Dendrite Morphogenesis Negative Regulation Of TORC1 Signaling Negative Regulation Of Reproductive Process P53 Binding Positive Regulation Of Axonogenesis Regulation Of TOR Signaling Positive Regulation Of Kinase Activity Epithelial Cell Proliferation Positive Regulation Of Protein Kinase Activity Negative Regulation Of Cell Growth Negative Regulation Of Canonical Wnt Signaling Pathway Anatomical Structure Homeostasis Cellular Response To UV Tissue Homeostasis Neuron Projection Extension Regulation Of Reproductive Process Developmental Cell Growth T Cell Receptor Signaling Pathway Response To UV Protein Localization To Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Axonogenesis Protein Dephosphorylation Dephosphorylation
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