CAPN5

Name	calpain 5
Structure
Interactors	2 interactors: FBXO7 MLH1
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion Cell Surface Synapse Extracellular Exosome
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Proteolysis Signal Transduction
Pathways	Degradation of the extracellular matrix
GWAS	Cognitive performance ( 19734545 )
Entrez ID	726
HPRD ID	03963
Ensembl ID	ENSG00000149260
Uniprot IDs	A0A140VKH4 E7EV01 O15484
PDB IDs	6P3Q
GO Terms Enriched among Interactors ?	Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Male Meiosis Chromosome Segregation MutLalpha Complex Lewy Body Core Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Lymphocyte Activation MutSalpha Complex Binding Regulation Of Mitotic Recombination Meiotic Telomere Clustering Regulation Of Lymphocyte Activation Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Leukocyte Activation Telomere Localization Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Spindle Midzone Assembly Regulation Of Cell Activation Cell Activation Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Isotype Switching To IgG Isotypes Resolution Of Meiotic Recombination Intermediates ATP-dependent DNA Damage Sensor Activity Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Isotype Switching Homologous Chromosome Pairing At Meiosis Positive Regulation Of Isotype Switching Mismatch Repair Somatic Diversification Of Immunoglobulins Involved In Immune Response Reciprocal Meiotic Recombination Synaptonemal Complex Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion