THBS4

Description		thrombospondin 4
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Sarcoplasmic Reticulum Extracellular Matrix Extracellular Exosome
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Growth Factor Activity Heparin Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Response To Unfolded Protein Cell Adhesion Signal Transduction Negative Regulation Of Angiogenesis Regulation Of Tissue Remodeling Response To Endoplasmic Reticulum Stress Behavioral Response To Pain Tissue Remodeling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Myoblast Migration Positive Regulation Of Cell Division Endothelial Cell-cell Adhesion Positive Regulation Of Neutrophil Chemotaxis
Pathways		Signaling by PDGF
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Central corneal thickness ( 32528159) Intraocular pressure ( 29617998) Refractive error ( 32231278) Serum thyroid-stimulating hormone levels ( 25436638)
Interacting Genes		1 interacting genes: APP
Entrez ID		7060
HPRD ID		02836
Ensembl ID		ENSG00000113296
Uniprot IDs		B7Z832 E7ES19 P35443
PDB IDs
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle Very-low-density Lipoprotein Particle Neuron Projection Maintenance RAGE Receptor Binding
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