STK10

Description		serine/threonine kinase 10
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Body Specific Granule Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Intracellular Signal Transduction Protein Autophosphorylation Lymphocyte Aggregation Regulation Of Lymphocyte Migration
Pathways		Neutrophil degranulation RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		Fostamatinib
Diseases
GWAS		Colorectal cancer x fine particulate matter exposure levels interaction ( 33338681) Heel bone mineral density ( 30598549) High density lipoprotein cholesterol levels ( 30498476) Longevity ( 30294719) Motor fluctuations in levodopa treated Parkinson's disease ( 32733355) Red cell distribution width ( 32888494)
Interacting Genes		3 interacting genes: CEBPA MAP1LC3A RNF10
Entrez ID		6793
HPRD ID		06796
Ensembl ID		ENSG00000072786
Uniprot IDs		O94804
PDB IDs		2J7T 4AOT 4BC6 4EQU 4USD 4USE 5AJQ 5OWQ 5OWR 6EIM 6GTT 6HXF 6I2Y 7QGP
Enriched GO Terms of Interacting Partners?		Transcription Cis-regulatory Region Binding CHOP-C/EBP Complex Cellular Response To Metal Ion RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Cell Development Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Postsynapse To Nucleus Signaling Pathway Extrinsic Component Of Postsynaptic Density Membrane Cellular Response To Oxygen-glucose Deprivation Urea Metabolic Process HMG Box Domain Binding Response To Phenylpropanoid Urea Cycle Response To Metal Ion STAT Family Protein Binding Fat Cell Proliferation Ribosome-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Schwann Cell Proliferation Response To Iron(II) Ion Response To Oxygen-glucose Deprivation Autolysosome Cellular Response To Nitrogen Starvation Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Response To Nutrient Levels Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development Negative Regulation Of Glial Cell Proliferation Phosphatidylethanolamine Binding Glutamatergic Synapse Positive Regulation Of Myelination Response To Lead Ion Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation SMAD Protein Signal Transduction Cellular Response To Copper Ion P38MAPK Cascade Negative Regulation Of Cell Differentiation Negative Regulation Of Stem Cell Proliferation Brown Fat Cell Differentiation Granulocyte Differentiation
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