SPR

Description		sepiapterin reductase
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Sepiapterin Reductase (NADP+) Activity Alcohol Dehydrogenase (NADP+) Activity Oxidoreductase Activity NADP Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process
Pathways		Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation
Drugs		Oxaloacetate Ion Nicotinamide adenine dinucleotide phosphate Biopterin N-acetylserotonin
Diseases
GWAS		Diastolic blood pressure ( 27841878) Malaria ( 31844061) Systolic blood pressure ( 27841878)
Interacting Genes		4 interacting genes: CAMK2G CEBPA SUMO2 YWHAQ
Entrez ID		6697
HPRD ID		01632
Ensembl ID		ENSG00000116096
Uniprot IDs		P35270
PDB IDs		1Z6Z 4HWK 4J7U 4J7X 4XWY 4Z3K 6I6C 6I6F 6I6P 6I6T 6I6V 6I79 6USN 7DSF
Enriched GO Terms of Interacting Partners?		Calcium-dependent Protein Serine/threonine Phosphatase Activity Calcium- And Calmodulin-dependent Protein Kinase Complex Positive Regulation Of Proteolysis Protein Domain Specific Binding Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Vitamin B2 White Fat Cell Proliferation C/EBP Complex Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Phenylpropanoid Fat Cell Proliferation Regulation Of Skeletal Muscle Adaptation Urea Metabolic Process HMG Box Domain Binding Regulation Of Protein Catabolic Process Urea Cycle Regulation Of Proteolysis STAT Family Protein Binding Identical Protein Binding Regulation Of Monoatomic Ion Transport Response To Lithium Ion Transcription By RNA Polymerase I Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Interleukin-6-mediated Signaling Pathway Osteoblast Development Protein Tag Activity SUMO Transferase Activity Calcium/calmodulin-dependent Protein Kinase Activity Brown Fat Cell Differentiation Granulocyte Differentiation Positive Regulation Of Macrophage Activation Negative Regulation Of Stem Cell Proliferation Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Positive Regulation Of Catabolic Process Epithelial Cell Maturation Ubiquitin-like Protein Ligase Binding
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