SKOR2

Description		SKI family transcriptional corepressor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding Histone Deacetylase Binding SMAD Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Smoothened Signaling Pathway Cerebellum Morphogenesis Cerebellar Purkinje Cell Differentiation Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Smoothened Signaling Pathway Cell Development Regulation Of Dendrite Morphogenesis Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Neuroblast Proliferation
Pathways
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Chronotype ( 30696823) Daytime nap ( 33568662) Fruit consumption ( 32066663) Hip circumference adjusted for BMI ( 34021172) Iris heterochromicity ( 30895295) Menarche (age at onset) ( 25231870 27182965)
Interacting Genes		2 interacting genes: SMAD2 SMAD3
Entrez ID		652991
HPRD ID		19131
Ensembl ID		ENSG00000215474
Uniprot IDs		Q2VWA4
PDB IDs
Enriched GO Terms of Interacting Partners?		Paraxial Mesoderm Morphogenesis Mesoderm Morphogenesis SMAD Protein Complex Pericardium Development Trophoblast Cell Migration Heteromeric SMAD Protein Complex Embryonic Foregut Morphogenesis Nodal Signaling Pathway Co-SMAD Binding Primary MiRNA Processing Transforming Growth Factor Beta Receptor Binding I-SMAD Binding SMAD Protein Signal Transduction R-SMAD Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Endoderm Development MiRNA Processing Ureteric Bud Development Negative Regulation Of Ossification Gastrulation Mesonephric Epithelium Development Mesonephric Tubule Development Mesoderm Formation Phosphatase Binding Formation Of Primary Germ Layer Embryonic Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Kidney Epithelium Development Response To Transforming Growth Factor Beta Embryonic Skeletal System Morphogenesis Cis-regulatory Region Sequence-specific DNA Binding Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Skeletal System Morphogenesis Regulation Of Epithelial To Mesenchymal Transition Regulation Of Ossification Response To Glucose Embryonic Organ Morphogenesis Double-stranded DNA Binding Ameboidal-type Cell Migration Response To Monosaccharide Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Carbohydrate Anterior/posterior Pattern Specification Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway DNA-binding Transcription Factor Binding Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
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