SLC5A1

Description		solute carrier family 5 member 1
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GO Annotations	Cellular Component	Early Endosome Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Brush Border Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Intracellular Vesicle
	Molecular Function	Galactose Transmembrane Transporter Activity Myo-inositol:sodium Symporter Activity Water Transmembrane Transporter Activity D-glucose:sodium Symporter Activity Protein Binding Pentose Transmembrane Transporter Activity Fucose Transmembrane Transporter Activity Alpha-glucoside Transmembrane Transporter Activity Symporter Activity Solute:sodium Symporter Activity Galactose:sodium Symporter Activity Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity
	Biological Process	Alpha-glucoside Transport Intestinal D-glucose Absorption Monoatomic Ion Transport Sodium Ion Transport Pentose Transmembrane Transport Fucose Transmembrane Transport Galactose Transmembrane Transport Myo-inositol Transport Transepithelial Water Transport Renal D-glucose Absorption Transmembrane Transport D-glucose Import Across Plasma Membrane Sodium Ion Import Across Plasma Membrane Intestinal Hexose Absorption Transport Across Blood-brain Barrier Chloride Transmembrane Transport D-glucose Transmembrane Transport
Pathways		Cellular hexose transport Defective SLC5A1 causes congenital glucose/galactose malabsorption (GGM) Intestinal hexose absorption
Drugs		Sotagliflozin
Diseases
GWAS		1,5-anhydroglucitol levels ( 28588231) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) GLP-1 levels in response to oral glucose tolerance test (120 minutes) ( 29093273)
Interacting Genes		1 interacting genes: HSPA1A
Entrez ID		6523
HPRD ID		01668
Ensembl ID		ENSG00000100170
Uniprot IDs		P13866
PDB IDs		7SL8 7SLA 7WMV 7YNI
Enriched GO Terms of Interacting Partners?		Denatured Protein Binding C3HC4-type RING Finger Domain Binding Death Receptor Agonist Activity ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Positive Regulation Of Microtubule Nucleation Cellular Response To Unfolded Protein Negative Regulation Of Inclusion Body Assembly Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Inclusion Body Assembly Negative Regulation Of Mitochondrial Membrane Permeability Inclusion Body Negative Regulation Of Membrane Permeability Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Misfolded Protein Binding Regulation Of Microtubule Nucleation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Chaperone-mediated Protein Complex Assembly Regulation Of Mitotic Spindle Assembly Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Aggresome Disordered Domain Specific Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Refolding ATP-dependent Protein Folding Chaperone COP9 Signalosome Cellular Response To Topologically Incorrect Protein Positive Regulation Of Microtubule Polymerization Regulation Of Spindle Assembly Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Organization Positive Regulation Of RNA Splicing Transcription Regulator Inhibitor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Heat Regulation Of Erythrocyte Differentiation Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Protein Folding Chaperone Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Regulation Of Microtubule Polymerization Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Cytokine-mediated Signaling Pathway Heat Shock Protein Binding Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Interleukin-8 Production
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