PMEL

Description		premelanosome protein
Image
GO Annotations	Cellular Component	Extracellular Region Endosome Multivesicular Body Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Multivesicular Body Membrane Cis-Golgi Network Membrane Melanosome Membrane Melanosome Extracellular Exosome Multivesicular Body, Internal Vesicle
	Molecular Function	Protein Binding Identical Protein Binding
	Biological Process	Melanosome Organization Melanin Biosynthetic Process Positive Regulation Of Melanin Biosynthetic Process
Pathways		Regulation of MITF-M-dependent genes involved in pigmentation
Drugs		Tebentafusp
Diseases
GWAS		Anorexia nervosa ( 28494655) Asthma ( 31619474) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Vitiligo ( 22951725)
Novel Interacting Genes		1 novel interacting genes: LRP1
Interacting Genes
Entrez ID		6490
HPRD ID		01117
Ensembl ID		ENSG00000185664
Uniprot IDs		P40967
PDB IDs		1TVB 1TVH 3CC5 4IS6 5EU3 5EU4 5EU5 5EU6 6VM7 6VM8 6VM9 6VMA 6VMC 7PHR 9JST 9JSU 9JSV 9JSW 9JSX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcytosis Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Positive Regulation Of Reverse Cholesterol Transport Regulation Of Transcytosis Lipoprotein Particle Receptor Binding Astrocyte Activation Involved In Immune Response Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Positive Regulation Of Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Amyloid-beta Clearance By Cellular Catabolic Process Amyloid-beta Clearance By Transcytosis Clathrin Heavy Chain Binding Regulation Of Lysosomal Protein Catabolic Process Lipoprotein Transport Plasma Membrane Protein Complex Astrocyte Activation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Heparan Sulfate Proteoglycan Binding Low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Transcytosis Regulation Of Amyloid-beta Clearance Cargo Receptor Activity Aorta Morphogenesis Regulation Of Extracellular Matrix Disassembly Amyloid-beta Clearance Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Amyloid-beta Metabolic Process Scavenger Receptor Activity Apoptotic Cell Clearance Positive Regulation Of Cholesterol Efflux Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Cholesterol Transport Regulation Of Cholesterol Efflux Cellular Response To Amyloid-beta Endocytic Vesicle Membrane Receptor Internalization Regulation Of SMAD Protein Signal Transduction Regulation Of Extracellular Matrix Organization Regulation Of Smooth Muscle Cell Migration Artery Morphogenesis Clathrin-coated Pit Retinoid Metabolic Process Regulation Of Cholesterol Transport Response To Amyloid-beta Positive Regulation Of Protein Localization To Plasma Membrane
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