ST3GAL4

Description		ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase
	Biological Process	Protein Glycosylation Lipid Metabolic Process Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing Positive Regulation Of Blood Coagulation Cognition Sialylation Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 20686565 24097068 25961943) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels ( 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) High light scatter reticulocyte count ( 32888494) LDL cholesterol ( 25961943 24097068 30275531 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757) Low density lipoprotein cholesterol levels ( 33339817 32154731) Mean platelet volume ( 27863252 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Monocyte count ( 32888494) Mumps ( 28928442) N-glycan levels ( 31163085) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 31666285 33547301 29403010 33339817) Soluble E-selectin levels ( 31217265) Total cholesterol levels ( 33339817 28334899 30275531) vWF levels ( 30586737)
Novel Interacting Genes		1 novel interacting genes: GGCX
Interacting Genes		2 interacting genes: ARHGDIA CD8B
Entrez ID		6484
HPRD ID		00084
Ensembl ID		ENSG00000110080
Uniprot IDs		A0A7I2V5F3 A0A7P0RGI5 Q11206 Q6IBE6
PDB IDs
Enriched GO Terms of Interacting Partners?		Rho GDP-dissociation Inhibitor Activity Vitamin Binding Gamma-glutamyl Carboxylase Activity Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion Regulation Of Bone Development Vitamin K Metabolic Process Regulation Of Synaptic Vesicle Cycle MHC Class I Protein Binding T Cell Receptor Complex Regulation Of Ketone Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process
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