ST3GAL4

Name	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Structure	No pdb structure
Novel Interactors	1 novel interactors: GGCX
Interactors	2 interactors: ARHGDIA CD8B
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity Beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide Alpha-2,3- Sialyltransferase
	Biological Process	Protein Glycosylation Lipid Metabolic Process Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing Positive Regulation Of Blood Coagulation Cognition Sialylation Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a N-Glycan antennae elongation Termination of O-glycan biosynthesis
GWAS	Apolipoprotein A1 levels ( 32203549 ) Apolipoprotein B levels ( 32203549 ) Aspartate aminotransferase levels ( 33547301 ) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809 ) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809 ) Cholesterol, total ( 20686565 24097068 25961943 ) Coronary artery disease ( 29212778 ) Factor VIII levels ( 30586737 ) HDL cholesterol levels ( 32203549 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Height ( 31562340 ) High light scatter reticulocyte count ( 32888494 ) LDL cholesterol ( 25961943 24097068 30275531 20686565 ) LDL cholesterol levels ( 32203549 28334899 30698716 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757 ) Low density lipoprotein cholesterol levels ( 33339817 32154731 ) Mean platelet volume ( 27863252 32888494 ) Medication use (HMG CoA reductase inhibitors) ( 31015401 ) Metabolite levels ( 23823483 ) Monocyte count ( 32888494 ) Mumps ( 28928442 ) N-glycan levels ( 31163085 ) Platelet count ( 27863252 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 ) Refractive error ( 32231278 ) Serum alkaline phosphatase levels ( 31666285 33547301 29403010 33339817 ) Soluble E-selectin levels ( 31217265 ) Total cholesterol levels ( 33339817 28334899 30275531 ) vWF levels ( 30586737 )
Entrez ID	6484
HPRD ID	00084
Ensembl ID	ENSG00000110080
Uniprot IDs	A0A7I2V5F3 A0A7P0RGI5 Q11206 Q6IBE6
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Rho GDP-dissociation Inhibitor Activity Vitamin Binding Gamma-glutamyl Carboxylase Activity Negative Regulation Of Bone Development Negative Regulation Of Testosterone Biosynthetic Process Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Neurotransmitter Secretion Regulation Of Bone Development Vitamin K Metabolic Process Regulation Of Synaptic Vesicle Cycle MHC Class I Protein Binding T Cell Receptor Complex Regulation Of Ketone Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Steroid Metabolic Process