P2RY12

Gene Name		purinergic receptor P2Y, G-protein coupled, 12
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Gene Ontology Annotations	Cellular Component	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Basal Plasma Membrane Cell Surface Intrinsic Component Of Membrane
	Molecular Function	G-protein Coupled Adenosine Receptor Activity ADP Receptor Activity Guanyl-nucleotide Exchange Factor Activity
	Biological Process	Adenosine Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Blood Coagulation Hemostasis Negative Regulation Of Norepinephrine Secretion Cell Projection Organization Platelet Activation G-protein Coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Ion Transport Protein Kinase B Signaling Positive Regulation Of GTPase Activity Negative Regulation Of Cell Differentiation Regulation Of Calcium Ion Transport Platelet Aggregation Calcium Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Nucleotide-like (purinergic) receptors Class A/1 (Rhodopsin-like receptors) Signal amplification Metabolic disorders of biological oxidation enzymes GPCR ligand binding P2Y receptors GPCR downstream signaling G alpha (i) signalling events Platelet activation, signaling and aggregation ADP signalling through P2Y purinoceptor 12
Drugs		Ticlopidine Treprostinil Clopidogrel Epoprostenol Prasugrel Ticagrelor
Diseases
GWAS
Protein-protein Interactions		1 interactors: GNAI2
Entrez ID		64805
HPRD ID		02743
Ensembl ID
Uniprot IDs		A8K7T1 Q9H244
PDB IDs		1T78 1VZ1 1Y9C
Enriched GO Terms of Interacting Partners?		Adenosine Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Negative Regulation Of CAMP Biosynthetic Process Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Regulation Of Cyclase Activity Activation Of MAPKK Activity Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Calcium Ion Transport Platelet Activation Response To Nutrient Activation Of Protein Kinase Activity Regulation Of Synaptic Transmission
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