SI

Description		sucrase-isomaltase
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GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Brush Border Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Catalytic Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Oligo-1,6-glucosidase Activity Sucrose Alpha-glucosidase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Alpha-glucosidase Activity
	Biological Process	Carbohydrate Metabolic Process Sucrose Catabolic Process Polysaccharide Digestion Disaccharide Catabolic Process
Pathways		Digestion of dietary carbohydrate Intestinal saccharidase deficiencies Intestinal saccharidase deficiencies
Drugs		Acarbose Scopolamine
Diseases		Congenital sucrase-isomaltase deficiency; Disaccharide intolerance I
GWAS		1,5-anhydroglucitol levels ( 28588231) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: ADRB2 PRKACA
Entrez ID		6476
HPRD ID		01962
Ensembl ID		ENSG00000090402
Uniprot IDs		P14410
PDB IDs		3LPO 3LPP
Enriched GO Terms of Interacting Partners?		Response To Cold Regulation Of Muscle Contraction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Regulation Of Macroautophagy Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Temperature Stimulus Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Muscle System Process Beta2-adrenergic Receptor Activity Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy Regulation Of Metal Ion Transport Regulation Of Autophagy AMPA Selective Glutamate Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Protein Localization To Lipid Droplet Positive Regulation Of Autophagosome Maturation Heat Generation Multicellular Organismal-level Homeostasis Modulation Of Chemical Synaptic Transmission CAMP-dependent Protein Kinase Activity Channel Activator Activity Diet Induced Thermogenesis Regulation Of System Process Adrenergic Receptor Activity Cilium CAMP-dependent Protein Kinase Complex High-density Lipoprotein Particle Assembly Mitochondrial Protein Catabolic Process CAMP/PKA Signal Transduction Vascular Endothelial Cell Response To Laminar Fluid Shear Stress Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Cellular Response To Parathyroid Hormone Stimulus Cellular Response To Glucagon Stimulus Interleukin-2-mediated Signaling Pathway Cellular Response To Epinephrine Stimulus Nucleotide-activated Protein Kinase Complex Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Vascular Endothelial Cell Response To Fluid Shear Stress Response To Parathyroid Hormone Cellular Response To Cold Response To Epinephrine
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