ERAP2

Description		endoplasmic reticulum aminopeptidase 2
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Proteolysis Regulation Of Blood Pressure Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Catabolic Process
Pathways		Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Ankylosing spondylitis ( 23749187) Arthritis (juvenile idiopathic) ( 33106285) Aspartate aminotransferase levels ( 33547301) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 30072576) Body mass index ( 26426971) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Diastolic blood pressure night-to-day ratio in hypertension ( 29973135) Inflammatory bowel disease ( 23128233 28067908) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Pediatric autoimmune diseases ( 26301688) Urate levels (BMI interaction) ( 25811787)
Novel Interacting Genes		1 novel interacting genes: CNTN4
Interacting Genes
Entrez ID		64167
HPRD ID		14306
Ensembl ID		ENSG00000164308
Uniprot IDs		A0AAQ5BHS6 B2R769 Q6P179
PDB IDs		3SE6 4E36 4JBS 5AB0 5AB2 5CU5 5J6S 5K1V 6EA4 7NSK 7NUP 7P7P 7PFS 7SH0
Enriched GO Terms of Interacting Partners?		Neuron Projection Fasciculation Neuron Cell-cell Adhesion Axonal Fasciculation Dendrite Self-avoidance Cell-cell Adhesion Mediator Activity Neuron Recognition Negative Regulation Of Neuron Differentiation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Recognition Side Of Membrane Regulation Of Neuron Differentiation Axon Guidance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Axonogenesis Regulation Of Synaptic Plasticity Neuron Projection Morphogenesis Neuron Projection Guidance Synapse Organization Cell Projection Morphogenesis Brain Development
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