XPNPEP3

Description		X-prolyl aminopeptidase 3
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Aminopeptidase Activity Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Hydrolase Activity Manganese Ion Binding Protein Homodimerization Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Glomerular Filtration Proteolysis Protein Processing
Pathways
Drugs
Diseases		Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) C-reactive protein levels ( 30388399) Experiencing mood swings ( 29500382) Low density lipoprotein cholesterol levels ( 32154731) Refractive error ( 32231278) Schizophrenia ( 28991256)
Novel Interacting Genes		2 novel interacting genes: CYB5R3 L3MBTL2
Interacting Genes
Entrez ID		63929
HPRD ID		10052
Ensembl ID		ENSG00000196236
Uniprot IDs		A0A087X0Z2 Q9NQH7
PDB IDs		5X49
Enriched GO Terms of Interacting Partners?		Nitric-oxide Synthase Complex Cytochrome-b5 Reductase Activity, Acting On NAD(P)H Nitrite Reductase (NO-forming) Activity Histone H4K20me1 Reader Activity Histone H4K20me2 Reader Activity Hemoglobin Complex Ectoderm Development Nitric Oxide Biosynthetic Process Sterol Biosynthetic Process Nitric Oxide Metabolic Process FAD Binding Reactive Nitrogen Species Metabolic Process Cholesterol Biosynthetic Process Blood Circulation Steroid Biosynthetic Process Azurophil Granule Lumen Promoter-specific Chromatin Binding Stem Cell Proliferation Lipid Droplet
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