EEFSEC

Description		eukaryotic elongation factor, selenocysteine-tRNA specific
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GO Annotations	Cellular Component	Nucleus Cytoplasm Ribonucleoprotein Complex
	Molecular Function	TRNA Binding Nucleotide Binding Translation Elongation Factor Activity GTPase Activity GTP Binding Hydrolase Activity Selenocysteine Insertion Sequence Binding Ribonucleoprotein Complex Binding
	Biological Process	Selenocysteine Incorporation Translation
Pathways		Selenocysteine synthesis
Drugs
Diseases
GWAS		Airflow obstruction in ever smokers ( 31879980) Asthma ( 32296059) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) FEV1 ( 30804560) Gestational age at birth (maternal effect) ( 28877031) Hypospadias ( 25108383) Lung function (FEV1/FVC) ( 30804560 28166213) Menarche (age at onset) ( 21102462 25231870) Monocyte count ( 32888494) Platelet distribution width ( 32888494) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Preterm birth (maternal effect) ( 28877031) Red cell distribution width ( 32888494) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)
Interacting Genes		1 interacting genes: CEBPA
Entrez ID		60678
HPRD ID		07409
Ensembl ID		ENSG00000132394
Uniprot IDs		C9J8T0 P57772
PDB IDs		5IZK 5IZL 5IZM 7ZJW
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex CHOP-C/EBP Complex White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion HMG Box Domain Binding Response To Phenylpropanoid Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway STAT Family Protein Binding Osteoblast Development Fat Cell Proliferation Brown Fat Cell Differentiation Granulocyte Differentiation Positive Regulation Of Macrophage Activation Negative Regulation Of Stem Cell Proliferation Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation Acute-phase Response Integrated Stress Response Signaling Macrophage Differentiation Response To Dexamethasone Animal Organ Regeneration Regulation Of Macrophage Activation Inner Ear Development Acute Inflammatory Response Cellular Response To Xenobiotic Stimulus Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Initiation Energy Homeostasis Response To Vitamin Stem Cell Proliferation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Stem Cell Proliferation Chromatin DNA Binding Kinase Binding Notch Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
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